Invitrogen™ SIGLEC5/SIGLEC14 Monoclonal Antibody (1A5), FITC

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA528138

Product Code. 16302444

Description

This antibody recognizes human Siglec-5 (Sialic acid-binding Ig-like lectin 5), otherwise known as CD170, a novel sialic-acid-binding Ig-like lectin, and member of the Ig superfamily, expressed by dendritic cells (DCs), activated macrophages, neutrophils, and cells of the monocyte/myeloid lineage.

SIGLEC5 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Specifications

• Antigen: SIGLEC5/SIGLEC14
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 1% BSA and 0.09% sodium azide
• Gene Accession No.: O15389, Q08ET2
• Gene Symbols: SIGLEC14, SIGLEC5
• Immunogen: Siglec-5-Fc protein, consisting of the full-length extracellular region of human Siglec-5, fused with the Fc region of human IgG1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: 1A5
• Conjugate: FITC
• Gene: SIGLEC5
• Gene Alias: CD170; CD33 antigen-like 2; CD33L2; LLNLR-470E3.1; OB-binding protein 2; OBBP2; OB-BP2; obesity-binding protein 2; sialic acid binding Ig like lectin 14; sialic acid binding Ig like lectin 5; sialic acid binding Ig-like lectin 14; sialic acid binding Ig-like lectin 5; sialic acid-binding Ig-like lectin 14; Sialic acid-binding Ig-like lectin 5; sialic acid-binding immunoglobulin-like lectin 5; SIGLEC14; siglec-14; SIGLEC5; Siglec-5; UNQ294/PRO333
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100049587, 8778
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
• Form: Liquid