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Invitrogen™ SIGLEC11 Polyclonal Antibody

Product Code. 12838892
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12838892 100 μg 100µg
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Product Code. 12838892 Supplier Invitrogen™ Supplier No. PA520743

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Description

Rabbit Polyclonal Antibody

Despite the predicted molecular weight, Siglec11 often migrates at a higher molecular weight in SDS-PAGE, presumably due to post-translational modifications. A suggested positive control is HepG2 cell lysate. PA5-20743 can be used with blocking peptide PEP-0857.

Siglecs are sialic acid-binding lectins of the immunoglobulin superfamily that are mainly expressed in cells of the hematopoietic system. Siglec11 is unlike other siglecs in that it binds specifically to alpha2-8-linked sialic acids and is not found in peripheral blood leukocytes but instead on macrophages of various tissues. Siglec11 is highly homologous to Siglec10 over their extracellular domain but not over their cytoplasmic domain, suggesting that Siglec11 arose through gene duplication followed by a recombination event involving another ancestral siglec gene. Following treatment of Siglec11-transfected cells with pervanadate, Siglec11 becomes tyrosine-phosphorylated and strongly associates with SHP-1 and SHP-2. At least five isoforms of Siglec11 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIGLEC11
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SIGLEC11
Gene Accession No. Q96RL6
Gene Alias sialic acid binding Ig like lectin 11; sialic acid binding Ig-like lectin 11; sialic acid-binding Ig-like lectin 11; Sialic acid-binding lectin 11; Siglec; SIGLEC11; siglec-11; UNQ9222/PRO28718
Gene Symbols SIGLEC11
Host Species Rabbit
Immunogen An 18 amino acid peptide from near the carboxy terminus of human Siglec11.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114132
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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