Invitrogen™ SIAH1 Recombinant Rabbit Monoclonal Antibody (PSH0-46)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA549361

Product Code. 17981031

Description

Sequence Similarities: 100% Mouse/Rat. Tissue Specificity: Widely expressed at a low level. Down-regulated in advanced hepatocellular carcinomas. Positive Control: Jurkat cell lysate, HeLa cell lysate, HepG2 cell lysate, A549 cell lysate, human brain tissue, human testis tissue, mouse brain tissue, mouse testis tissue, rat brain tissue, rat testis tissue, A549. Subcellular Location: Cytoplasm, Nucleus. Predicted band size: 31.1 kDa.

This gene encodes a protein that is a member of the seven in absentia homolog family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Specifications

• Antigen: SIAH1
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P61092, Q06985, Q8IUQ4, Q920M9
• Gene Symbols: SIAH1, Siah1a, Siah1b
• Immunogen: Synthetic peptide within human siah1 aa 1-50 / 282.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: PSH0-46
• Conjugate: Unconjugated
• Gene: SIAH1
• Gene Alias: AA960570; AA982064; AI853500; E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase SIAH1A; E3 ubiquitin-protein ligase SIAH1B; FLJ08065; h HUMSIAH; hSIAH1; HUMSIAH; mSiah-1a; RING-type E3 ubiquitin transferase SIAH1; RING-type E3 ubiquitin transferase SIAH1A; RING-type E3 ubiquitin transferase SIAH1B; seven in absentia 1A; seven in absentia 1B; seven in absentia homolog 1; Seven in absentia homolog 1a; Seven in absentia homolog 1b; SIAH; siah E3 ubiquitin protein ligase 1; SIAH1; siah-1; Siah1a; Siah-1a; Siah1b; siah-1b; Sinh1a; Sinh1b
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 110337437, 140941, 20437, 20438, 6477
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid