Invitrogen™ SHOC2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA552659

Product Code. 15730611

Description

Immunogen sequence: LEENKLESLP NEIAYLKDLQ KLVLTNNQLT TLPRGIGHLT NLTHLGLGEN LLTHLPEEIG TLENLEELYL NDNPNLHSLP FELALCSKLS IMSIENCPLS HLPPQIVA Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 100%.

SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

Specifications

• Antigen: SHOC2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Shoc2
• Gene Alias: AU017287; KIAA0862; Leucine-rich repeat protein SHOC-2; mKIAA0862; Protein soc-2 homolog; protein sur-8 homolog; Ras-binding protein SUR-8; RP11-348N5.2; Shoc2; SHOC2 leucine-rich repeat scaffold protein; SHOC2, leucine rich repeat scaffold protein; SIAA0862; SOC2; soc-2 (suppressor of clear) homolog; soc-2 (suppressor of clear) homolog (C. elegans); soc-2 suppressor of clear homolog; soc-2 suppressor of clear homolog (C. elegans); suppressor of clear, C. elegans, homolog of; SUR8
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 309548, 56392, 8036
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O88520, Q6AYI5, Q9UQ13
• Gene Symbols: Shoc2
• Immunogen: Recombinant protein corresponding to Human SHOC2. Recombinant protein control fragment (Product #RP-89604).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG