Invitrogen™ SHISA4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5140121

Product Code. 17824640

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: RQQLQSPFEG QEIPMTGIPV QPVYPYPQDP QAGPA Highest antigen sequence indentity to the following orthologs: Mouse - 86%, Rat - 83%.

SHISA4 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.

Specifications

• Antigen: SHISA4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SHISA4
• Gene Alias: 9330132O05Rik; C1orf40; mShisa4; Protein shisa-4; shisa family member 4; shisa homolog 4; SHISA4; Tmem58; transmembrane protein 58; UNQ583/PRO1153
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 149345
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96DD7
• Gene Symbols: SHISA4
• Immunogen: Recombinant protein corresponding to Human SHISA4. Recombinant protein control fragment (Product #RP-109144).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG