Invitrogen™ SHFM3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA570333

Product Code. 15838743

Description

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

Specifications

• Antigen: SHFM3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FBXW4
• Gene Alias: Dac; dactylaplasia; dactylin; dactylyn; F-box and WD repeat domain containing 4; F-box and WD-40 domain protein 4; F-box and WD-40 domain-containing protein 4; F-box protein Fbw4; F-box/WD repeat protein 4; F-box/WD repeat-containing protein 4; FBW4; FBWD4; FBXW4; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 4; protein hagoromo; SHFM3; SHSF3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 309444
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: 0
• Gene Symbols: FBXW4
• Immunogen: synthetic peptide corresponding to a region of rat SHFM3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG