Invitrogen™ SH3BP4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA557992

Product Code. 15765881

Description

Immunogen sequence: EGTLIDLSEG FSETSFNDIK VPSPSALLVD NPTPFGNAKE VIAIKDYCPT NFTTLKFSKG DHLYVLDTSG GEWWYAHNT Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

SH3BP4 was initially isolated as a novel cDNA using differential display analysis using cultured human corneal fibroblasts. The protein contains three Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. SH3BP4 has been shown to interact with specific endocytic proteins such as clathrin, dynamin, and the transferrin receptor (TfR) and localizes to TfR-containing coated pits and vesicles. It is thought to be involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of TfR. At least two isoforms of SH3BP4 are known to exist.

Specifications

• Antigen: SH3BP4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SH3BP4
• Gene Alias: AI594717; AW227605; BOG25; EHB10; EH-binding protein 10; SH3 domain binding protein 4; SH3 domain-binding protein 4; SH3 domain-binding protein 4; SH3-domain binding protein 4; Sh3bp4; SH3-domain binding protein 4; si:dkey-57b6.3; Transferrin receptor-trafficking protein; TTP
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23677
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9P0V3
• Gene Symbols: SH3BP4
• Immunogen: Recombinant protein corresponding to Human SH3BP4. Recombinant protein control fragment (Product #RP-96078).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG