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Tocris Bioscience™ SGC 0946
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Product Code. 18719726
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2 mg
Unit Size:
2mg
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18719726 2 mg 2mg
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Product Code. 18719726 Supplier Tocris Bioscience™ Supplier No. 4541/2

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Description

Highly potent and selective DOT1L inhibitor; cell permeable

SGC 0946 is a highly potent DOT1L methyltransferase inhibitor (Kd = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1.

To request the negative control for SGC0946, please fill out the SGC0649 request form on the SGC website.

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Specifications

Chemical Name or Material 1-[3-[[[(2 R,3 S,4 R,5 R)-5-(4-Amino-5-bromo-7 H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea
CAS 1561178-17-3
Quantity 2 mg
Target Lysine Methyltransferase Inhibitors
Molecular Formula C28H40BrN7O4
Purity 99%
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