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Invitrogen™ SFXN4 Polyclonal Antibody
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Product Code. 15878373
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Quantity:
100 μL
Unit Size:
100µL
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15878373 100 μL 100µL
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Product Code. 15878373 Supplier Invitrogen™ Supplier No. PA569967

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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Human: 100%.

Sideroflexin 4 (SFXN4) is a gene primarily associated with mitochondrial functionality and disease. It encodes a protein that is crucial for the assembly of complex I within mitochondria, a critical component of the electron transport chain. Mutations in SFXN4 can result in mitochondrial diseases due to its pivotal role in this process. Interestingly, SFXN4 belongs to the sideroflexin family, traditionally known for amino acid transport, indicating a functional evolution to support mitochondrial assembly. In the context of cancer, specifically ovarian cancer, SFXN4 is involved in the synthesis of iron-sulfur clusters (Fe-S), which are essential for cell growth and division. Inhibition of SFXN4 disrupts Fe-S biogenesis, highlighting its potential as a target for anti-cancer therapy. Additionally, SFXN4's expression and function have been correlated with immune pathways in hepatocellular carcinoma, suggesting broader implications in cancer biology. Knockdown studies and natural mutations demonstrate SFXN4's role in mitochondrial diseases, including macrocytic anemia observed in zebrafish models and implications in human mitochondriopathy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SFXN4
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene SFXN4
Gene Accession No. Q6P4A7
Gene Alias BCRM1; Breast cancer resistance marker 1; COXPD18; SFXN4; sideroflexin 4; sideroflexin-4
Gene Symbols SFXN4
Host Species Rabbit
Immunogen synthetic peptide directed towards the N terminal region of human SFXN4.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 119559
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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