SFTPB Precursor Monoclonal Antibody (SPB01 (1-2-A5-9)), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA513975

Product Code. 11314963

Description

MA5-13975 targets Surfactant Protein B (Precursor) in IF and IHC (P) applications and shows reactivity with Human and Rat samples. The MA5-13975 immunogen is recombinant pro-surfactant protein B.

Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventillation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.

Specifications

• Antigen: SFTPB Precursor
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P07988, P22355
• Gene Symbols: SFTPB
• Immunogen: Recombinant pro-surfactant protein B
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Immunohistochemistry (Paraffin)
• Clone: SPB01 (1-2-A5-9)
• Conjugate: Unconjugated
• Gene: SFTPB
• Gene Alias: 18 kDa pulmonary-surfactant protein; 6 kDa protein; PSP-B; Pulmonary surfactant-associated protein B; pulmonary surfactant-associated proteolipid SPL(Phe); SFTB3; SFTP3; SFTPB; SMDP1; SP-B; surfactant associated protein B; surfactant protein B; surfactant pulmonary-associated protein B; surfactant, pulmonary-associated protein B
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 192155, 6439
• Content And Storage: 4° C
• Form: Liquid