SFRS2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 20371-1-AP-20UL

Product Code. 16879904

Description

The antibody has no cross reaction to SFRS2B.

SFRS2 is necessary for the splicing of pre-mRNA. The protein is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5′- and 3′-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. And it interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5′- and 3′-splice site binding components, U1 snRNP and U2AF. It binds to purine-rich RNA sequences, either 5′-AGSAGAGTA-3′ (S=C or G) or 5′-GTTCGAGTA-3′ and can bind to beta-globin mRNA and commit it to the splicing pathway.

Specifications

• Antigen: SFRS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SRSF2
• Gene Alias: PR264, Protein PR264, SC 35, SC35, SFRS2, SFRS2A, Splicing component, 35 kDa, Splicing factor SC35, SRp30b, SRSF2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20382, 494445, 6427
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunohistochemistry (Paraffin), Immunoprecipitation
• Concentration: 0.3 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q01130, Q62093, Q6PDU1
• Gene Symbols: Srsf2
• Immunogen: Peptide
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Human, Rat
• Product Type: Antibody
• Isotype: IgG