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Invitrogen™ SF3B1 Recombinant Rabbit Monoclonal Antibody (K01_2P45)

Description
SF3B1 Recombinant Monoclonal Antibody for ICC/IF, IHC (P), Western Blot
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex. The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specifications
Specifications
| Antigen | SF3B1 |
| Applications | Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry |
| Classification | Recombinant Monoclonal |
| Clone | K01_2P45 |
| Concentration | 1 mg/mL |
| Conjugate | Unconjugated |
| Formulation | 50mM tris glycine with 0.05% BSA, 150mM NaCl, 40% glycerol and 0.01% sodium azide; pH 7.4 |
| Gene | SF3B1 |
| Gene Accession No. | O75533, Q99NB9 |
| Gene Alias | 155kDa; 2810001M05Rik; AA409119; Hsh155; LOW QUALITY PROTEIN: splicing factor 3B subunit 1; MDS; pre-mRNA processing 10; pre-mRNA splicing factor SF3b, 155 kDa subunit; pre-mRNA-splicing factor SF3b 155 kDa subunit; PRP10; PRPF10; SAP 155; SAP155; SF3B1; SF3b155; spliceosome-associated protein 155; Splicing factor 3B subunit 1; splicing factor 3b subunit 1, 155kDa; splicing factor 3b, subunit 1; splicing factor 3b, subunit 1, 155 kDa; splicing factor 3b, subunit 1, 155kD; splicing factor 3b, subunit 1, 155kDa; TA-8; Targ4; transforming growth factor alpha regulated gene 4; tst; wu:fb99f09 |
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