Invitrogen™ SERPINB3/SERPINB4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
17990353	Invitrogen™ PA5145441	200 μL
17929852	Invitrogen™ PA5145442	20 μL

Description

Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine prote-ases, such as neutrophil elastase. In 1985, Dr. Jim Travis and Dr. R.W. Carrell designated an emerging family of serine protease inhibitors as the serpin fam-ily, which share homology in both primary amino acid sequence and tertiary structure. Serpins contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant ex-pression of serpin family members can contribute to a number of conditions, including emphysema (a-1 antitrypsin deficiency), fatal bleeding (elastase to thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). Human chromosome position 18q21.3 contains a cluster of serpins, including a tandem duplication of the SCCA gene, plasminogen activator inhibitor type 2, and maspin. SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2), and is mainly produced as SCCA1. The human SCCA1 gene encodes a 390 amino acid protein that was originally isolated from a metastatic cervical squamous cell carcinoma.

Specifications

• Antigen: SERPINB3/SERPINB4
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P29508, P48594
• Gene ID (Entrez): 6317, 6318
• Immunogen: Recombinant Human SCCA1/SCCA2 protein, Leu38-Gln215 (Accession #Q5K684).
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

• Concentration: 0.5 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Alias: 1110001H02Rik; 1110013A16Rik; HsT1196; LEUPIN; Peptidase inhibitor 11; PI11; PI-11; protease inhibitor (leucine-serpin); protein T4-A; RGD1562868; SCC; SCCA; SCCA1; SCCA-1; SCCA2; SCCA-2; SCCA2/SCCA1 fusion protein; SCCA-PD; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3A; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4; serine peptidase inhibitor, clade B, member 3A; serine protease inhibitor B3; serpin B3; Serpin B4; serpin family B member 3; serpin family B member 4; serpin peptidase inhibitor, clade B (ovalbumin), member 3; serpin peptidase inhibitor, clade B (ovalbumin), member 4; Serpinb3; Serpinb3a; SERPINB4; spb3; Sqn5; Squamous cell carcinoma antigen 1; squamous cell carcinoma antigen 2; SSCA1; T4-A
• Gene Symbols: Serpinb3, SERPINB4
• Isotype: IgG
• Purification Method: Antigen affinity chromatography, Protein A