Invitrogen™ Septin 2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA527485

Product Code. 13491587

Description

Recommended positive controls: NT2D1, IMR32, Jurkat, HeLa. Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (93%), Xenopus laevis (91%), Pig (98%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Septin 2 is a filament-forming cytoskeletal GTPase. Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. It is required for the progression through mitosis, and it forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation. Septin 2 also plays a role in ciliogenesis and collective cell movements.

Specifications

• Antigen: Septin 2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SEPTIN2
• Gene Alias: 2-Sep; AW208991; DIFF6; hNedd5; KIAA0158; mKIAA0158; NEDD5; Nedd-5; Neural precursor cell expressed developmentally down-regulated protein 5; neural precursor cell expressed, developmentally down-regulated 5; neural precursor cell expressed, developmentally down-regulated gene 5; Pnutl3; Sept2; septin 2; Septin2; septin-2; Vascular endothelial cell specific protein 11; Vesp11
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18000, 4735
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P42208, Q15019
• Gene Symbols: SEPTIN2
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Septin 2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG