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  6. Invitrogen™ Securin Recombinant Rabbit Monoclonal Antibody (K01_1Y21)

Invitrogen™ Securin Recombinant Rabbit Monoclonal Antibody (K01_1Y21)

Product Code. 30830091
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30825805 50 μL
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Product Code. 30830091 Supplier Invitrogen™ Supplier No. MA563683
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Estimated Shipment: 24-11-2026
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Description

Rabbit Recombinant Monoclonal Antibody

Securin Recombinant Monoclonal Antibody for IHC (P), Western Blot

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Securin
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone K01_1Y21
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 0.05% BSA, 150mM NaCl, 40% glycerol and 0.01% sodium azide; pH 7.4
Gene Pttg1
Gene Accession No. O95997, Q9CQJ7
Gene Alias AW555095; C87862; EAP1; Esp1-associated protein; ESP1-associated protein 1; HPTTG; MGC126883; MGC138276; Pituitary tumor transforming; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1; pituitary tumor-transforming gene 1 protein; PTTG; PTTG1; Pttg3; Securin; tumor-transforming protein 1; TUTR1
Gene Symbols Pttg1
Host Species Rabbit
Immunogen A synthetic peptide of human Securin.
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 30939, 9232
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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