Invitrogen™ Securin Recombinant Rabbit Monoclonal Antibody (24GB1495)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30275307	Invitrogen™ MA557654	100 μL
30276022	Invitrogen™ MA557655	20 μL

Description

Securin Recombinant Monoclonal Antibody for Western Blot, Flow

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Specifications

• Antigen: Securin
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human, Mouse
• Gene: Pttg1
• Gene Alias: AW555095; C87862; EAP1; Esp1-associated protein; ESP1-associated protein 1; HPTTG; MGC126883; MGC138276; Pituitary tumor transforming; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1; pituitary tumor-transforming gene 1 protein; PTTG; PTTG1; Pttg3; Securin; tumor-transforming protein 1; TUTR1
• Gene Symbols: Pttg1
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography

• Clone: 24GB1495
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O95997, Q9CQJ7
• Gene ID (Entrez): 30939, 9232
• Immunogen: A synthesized peptide derived from human Securin (aa 100-149).
• Product Type: Antibody