Invitrogen™ SEC61A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA588175

Product Code. 16526491

Description

Immunogen sequence: ARFSGNLLVS LLGTWSDTSS GGPARAYPVG GLCYYLSPPE SFGSVLEDPV HAVVYIVFML GSCAFFSKTW IEVSGSSAKD VAKQLKEQQM VMRGHRETSM VHELNRYIPT A; Positive Samples: A-549; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein.

The Sec61 complex is responsible for translocation of proteins across the rough endoplasmic reticulum membrane. Sec61 is composed of three subunits: alpha, beta, and gamma; that associate to form a heterotrimer. Multiple heterotrimers associate forming the ER translocon. Sec61 alpha is a polytopic protein that has ten membrane-spanning loops. Sec61 has been found to be tightly associated with membrane bound ribosomes, either directly or through adaptor proteins, and is required for assembly of membrane and secretory proteins.

Specifications

• Antigen: SEC61A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SEC61A1
• Gene Alias: AA408394; AA410007; homologue to sec61; HSEC61; protein transport protein SEC61 alpha subunit; protein transport protein Sec61 subunit alpha; protein transport protein Sec61 subunit alpha isoform 1; protein transport protein Sec61 subunit alpha isoform 1; protein transport protein Sec61 subunit alpha; SEC61; Sec61 alpha 1 subunit; Sec61 alpha 1 subunit (S. cerevisiae); Sec61 alpha subunit homolog; sec61 alpha-1; sec61 homolog; sec61 homologue; SEC61 translocon alpha 1 subunit; SEC61 translocon subunit alpha 1; SEC61, alpha subunit; SEC61A; SEC61A1; transport protein sec61 alpha subunit
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29927, 53421, 80843
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.98 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P61619, P61620, P61621
• Gene Symbols: SEC61A1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 310-420 of human SEC61A1 (NP_0374681).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG