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Scopolamine hydrobromide trihydrate, 99%, Thermo Scientific Chemicals
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Information
• Scopolamine hydrobromide trihydrate is a salt form of scopolamine, a tropane alkaloid derived from plants of the nightshade family (Solanaceae), mainly Hyoscyamus niger and Atropa belladonna
• Scopolamine hydrobromide trihydrate, demonstrates competitive anti-muscarinic activity blocking the actions of endogenous acetylcholine or exogenous agonists
• It also shows anti-spasmodic and anti-emetic activities
Applications
• It has been described that scopolamine inhibits muscarinic acetylcholine receptors (mAChRs) with some selectivity for M1 mAChRs
• It is structurally similar to acetylcholine and can antagonize acetylcholine activity mediated by muscarinic receptors located on structures innervated by postganglionic cholinergic nerves and on smooth muscles (that respond to acetylcholine but lack cholinergic innervation)
• Scopolamine hydrobromide trihydrate can induce amnesia in laboratory animals and so it is frequently used in animal models of memory deficit
• Scopolamine hydrobromide trihydrate is used to induce cognitive deficits in animal models of Alzheimer’s disease
• Scopolamine, has been employed in several studies to understand, identify, and characterize biological targets for Alzheimer's disease
Specifications
Specifications
Melting Point | 194.0°C to 197.0°C |
Color | White or Colorless |
Infrared Spectrum | Authentic |
Assay Percent Range | 99% |
Packaging | Glass bottle |
Quantity | 5 g |
Beilstein | 27, 102 |
Merck Index | 14, 8406 |
Specific Rotation Condition | −27° (20°C c=5,H2O) |
Specific Rotation | − 27.00 |
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Safety and Handling
- Scopolamine hydrobromide trihydrate
- Danger
- Acute toxicity Category 1
- Acute toxicity Category 2
- H310-Fatal in contact with skin.
- H330-Fatal if inhaled.
- H300-Fatal if swallowed.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
- P302+P352-IF ON SKIN: Wash with plenty of water/.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P310-Immediately call a POISON CENTER/doctor/.
- P361-Take off immediately all contaminated clothing.
RUO – Research Use Only