SCN9A Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA566430

Product Code. 15788178

Description

Immunogen sequence: RAYRRYRLRQN VKNISSIYIK DGDRDDDLLN KKDMAFDNVN ENSSP Highest antigen sequence identity to the following orthologs - mouse 91%, rat 89%.

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel′s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Specifications

• Antigen: SCN9A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SCN9A
• Gene Alias: SCN2A; NAC2; SCN2A1; SCN2A2; Nav1.1; NAC1; SCN1; SCN1A; Nav1.2; SCN3A; KIAA1356; NAC3; Nav1.3; Nav1.4; SCN4A; Nav1.5; SCN5A; Nav1.6; SCN8A; MED; Nav1.7; SCN9A; NENA; Nav1.8; SCN10A; Nav1.9; hNaN; SCN11A; SCN12A; SNS2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6335
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q15858
• Gene Symbols: SCN9A
• Immunogen: Recombit Human SCN9A
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

For Research Use Only