Invitrogen™ SCLY Monoclonal Antibody (3B2)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA521953

Product Code. 15599052

Description

Peptide Sequence: NSQFPGTQRL PNTCNFSIRG PRLQGHVVLA QCRVLMASVG AACHSDHGDQ PSPVLLSYGV PFDVARNALR LSVGRSTTRA EVDLVVQDLK QAVAQLEDQ.

The SCLY gene encodes selenocysteine lyase, an enzyme involved in selenium metabolism, which plays a critical role in the recycling of selenocysteine from selenoproteins. SCLY catalyzes the conversion of selenocysteine into alanine, releasing selenium for reuse in the biosynthesis of new selenoproteins. It is chiefly active in the liver and kidneys, contributing to maintaining selenium homeostasis, which is vital for numerous biological functions due to selenium's role in antioxidant defense and thyroid hormone metabolism. Alterations in SCLY function or expression can affect selenium levels in the body and are associated with disorders related to oxidative stress and metabolic imbalances. Given the importance of selenium in cellular protection and immune function, SCLY is also of interest in studies focusing on dietary supplementation and disease prevention strategies, particularly in conditions like cancer and cardiovascular diseases where oxidative damage is prevalent.

Specifications

• Antigen: SCLY
• Classification: Monoclonal
• Concentration: 0.2-1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q96I15
• Gene Symbols: Scly
• Immunogen: SCLY (NP_057594, 346 a.a. ~ 444 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Immunoprecipitation
• Clone: 3B2
• Conjugate: Unconjugated
• Gene: Scly
• Gene Alias: 9830169H08; A930015N15Rik; hSCL; mSCL; SCL; SCLY; Scly1; Scly2; Selenocysteine lyase; selenocysteine lyase; Selenocysteine reductase; selenocysteine reductase
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51540
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid