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  5. Tocris Bioscience™ SCIO 469 hydrochloride

Tocris Bioscience™ SCIO 469 hydrochloride

Product Code. 18044212
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18044212 10 mg 10mg
18014852 50 mg 50mg
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Product Code. 18044212 Supplier Tocris Bioscience™ Supplier No. 3528/10

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165.80 GBP valid until 2026-03-31
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Description

Selective p38 MAPK inhibitor

SCIO 469 hydrochloride is a selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Displays approximately 10-fold selectivity for p38α over p38β and 2000-fold selectivity for p38α over 20 other kinases. Reduces p38α phosphorylation in multiple myeloma cells in vitro and in vivo; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib -induced cytotoxicity against multiple myeloma cells.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 309913-83-5
Molecular Formula C27H30ClFN4O3

Specifications

Quantity 10 mg
Formula Weight 549.46
Purity >98%
Molecular Weight (g/mol) 513.01
Chemical Name or Material SCIO 469 hydrochloride
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