Invitrogen™ SCIN Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA522243

Product Code. 13249508

Description

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (92%), Rat (92%), Pig (94%), Chicken (83%), Bovine (87%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The SCIN gene, also known as scinderin, encodes for a calcium-dependent actin filament-severing protein that is involved in the regulation of the cytoskeleton. It plays a significant role in actin filament dynamics, influencing cellular processes such as cell shape, motility, secretion, and division. SCIN has been identified as a novel oncogene, with its abnormal expression strongly correlated to various cancers, including glioma and uterine corpus endometrial carcinoma. Specific mutations like S673F and S381Y in SCIN are linked with poor prognosis and are potential targets for cancer diagnosis, prognosis, and treatment strategies.

Specifications

• Antigen: SCIN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SCIN
• Gene Alias: Adseverin; AW545522; Gelsolin-like protein; KIAA1905; SCIN; Scind; Scinderin
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 85477
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9Y6U3
• Gene Symbols: SCIN
• Immunogen: Recombinant protein encompassing a sequence within the center region of human SCIN. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG