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  5. STEMCELL Technologies SBI-0206965

STEMCELL Technologies SBI-0206965

Product Code. 17149991
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Quantity:
5 mg
10 mg
Unit Size:
10mg
5mg
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Product Code. 17149991

Brand: STEMCELL Technologies 1000270

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This item is not returnable. View return policy

Description

ULK1 and ULK2 kinase inhibitor

  • SBI-0206965 is an inhibitor of the autophagy initiator kinases ULK1 and ULK2 (IC50 = 108 nM and 711 nM, respectively; Egan et al.) SBI-0206965 is also a potent inhibitor of AMP-activated protein kinase (AMPK), a positive regulator of autophagy (Dite et al.)
  • Synergizes with mTOR inhibition to induce apoptosis and cell death in tumor cells (Egan et al.)
  • Suppresses autophagy induced by mTOR inhibition (Egan et al.)
  • Suppresses prosurvival autophagic responses in tumor cells through AMPK and ULK1 inhibition (Dite et al.)

Specifications

CAS 1884220-36-3
Quantity 10 mg
Molecular Formula C21H21BrN4O5
Purity ≥98%
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