SBE 13 hydrochloride, Tocris Bioscience™

Description

Potent and selective PLK1 inhibitor

Selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. Delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines. Transiently arrests cells cycle at G0/G1 in primary cells.

Specifications

• CAS: 1052532-15-6
• Molecular Formula: C24H28Cl2N2O4
• Quantity: 10mg
• Synonym: sbe13 hydrochloride, sbe 13 hydrochloride, sbe 13 hcl, n-4-6-chloro-3-pyridinyl methoxy-3-methoxyphenyl methyl-3,4-dimethoxybenzeneethanamine hydrochloride, n-4-6-chloropyridin-3-yl methoxy-3-methoxybenzyl-2-3,4-dimethoxyphenyl ethanamine, c24h27cln2o4.clh, sbe-13 hcl;sbe13 hcl, sbe 13 hydrochloride hplc, n-4-6-chloropyridin-3-yl methoxy-3-methoxyphenyl methyl-2-3,4-dimethoxyphenyl ethan-1-amine-hydrogen chloride 1/1
• InChI Key: QBGSVDJLQQXEGG-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl
• IUPAC Name: N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine;hydrochloride
• Molecular Weight (g/mol): 479.398
• PubChem CID: 11948807
• Formula Weight: 479.4
• Percent Purity: >99%
• Chemical Name or Material: SBE 13 hydrochloride