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STEMCELL Technologies SB202190

Product Code. 17110102
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25 mg
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17110102 25 mg 25mg
17100102 10 mg 10mg
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Product Code. 17110102 Supplier STEMCELL Technologies Supplier No. 72634

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Description

p38 MAPK inhibitor

  • SB202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively (Davies et al.; Jiang et al.) As a pyridinyl imidazole inhibitor, SB202190 directly binds p38 MAP kinases in the ATP binding pocket (Fox et al.)
  • Improves the self-renewal ability of neural stem cells from NPC1-deficient mice (Yang et al.)
  • Blocks adiponectin-mediated proliferation of hematopoietic stem cells (DiMascio et al.)
  • Reduces BMP3-mediated proliferation of C3H10T1/2 mesenchymal stem cells (Stewart et al.)
  • Induces cardiomyocyte differentiation from human embryonic stem cells (Graichen et al.)

Specifications

CAS 152121-30-7
Quantity 25 mg
Molecular Formula C20H14FN3O
Purity ≥98%
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