SB 431542, Tocris Bioscience™

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Product Code	Brand	Quantity
18799876	Tocris Bioscience 1614/1	1 mg
18795776	Tocris Bioscience 1614/10	10 mg
18064922	Tocris Bioscience™ 1614/50	50 mg

Description

SB 431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.

SB 431542 synthesized to cGMP guidelines also available.

For more information about how SB 431542 may be used, see our protocols: 3D Culture of Lung Alveolar Cells, Differentiation of Hematopoietic Progenitors from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Generating Vascular Organoids, Accelerated Induction of Cortical Neurons from hiPSCs .

Specifications

• CAS: 301836-41-9
• Molecular Formula: C22H16N4O3
• Formula Weight: 384.39

Safety and Handling

Recommended Storage : Store at Room Temperature