missing translation for 'onlineSavingsMsg'
Learn More
Learn More
SB 431542, Tocris Bioscience™
Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
POA
Specifications
| CAS | 301836-41-9 |
|---|---|
| Synonym | 4-4-2h-1,3-benzodioxol-5-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide |
Description
Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.SB 431542 synthesized to cGMP guidelines also available.
Specifications
| 301836-41-9 | |
| 4-4-2h-1,3-benzodioxol-5-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide |