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SB 431542, Tocris Bioscience™

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

£149.02 - £1170.85

Specifications

CAS 301836-41-9
Molecular Formula C22H16N4O3
Formula Weight 384.39
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Product Code Brand Quantity Price Quantity & Availability  
18799876
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Tocris
1614/1
1 mg
£149.02
1mg
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18795776
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Tocris
1614/10
10 mg
£276.45
10mg
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18064922
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Tocris Bioscience™
1614/50
50 mg
£1170.85
50mg
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Description

Description

SB 431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines.

SB 431542 synthesized to cGMP guidelines also available.

For more information about how SB 431542 may be used, see our protocols: 3D Culture of Lung Alveolar Cells, Differentiation of Hematopoietic Progenitors from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Generating Vascular Organoids, Accelerated Induction of Cortical Neurons from hiPSCs .

Specifications

Specifications

301836-41-9
C22H16N4O3
384.39
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