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  7. SB-334867 free base, MedChemExpress

SB-334867 free base, MedChemExpress

Product Code. 16496967
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16496967 5 mg 5mg
16474248 10 mg 10mg
16400587 50 mg 50mg
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Product Code. 16496967 Supplier Medchem Express Supplier No. HY10895A

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Description

MedChemExpress SB-334867 free base (SB334867A free base) is an excellent, selective and blood-brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.

SB-334867 free base (SB334867A free base) is an excellent, selective and blood-brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.

Specifications

Chemical Name or Material SB-334867 free base
CAS 792173-99-0
Color White
Purity Grade Notes Research
Molecular Formula C17H13N5O2
Quantity 5 mg
Synonym SB334867A free base
Solubility Information DMSO : 50 mg/mL (156.58 mM; Need ultrasonic) ∣0.1 M HCL : 6 mg/mL (18.79 mM; ultrasonic and adjust pH to 3 with HCl)
SMILES O=C(NC1=CC(OC(C)=N2)=C2C=C1)NC3=CC=NC4=CC=CN=C43
Molecular Weight (g/mol) 319.32
Formula Weight 319.32
Percent Purity 99.33%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neuromodulation
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Research purposes only

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