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SB 228357, Tocris Bioscience™

Product Code. 18095282
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Product Code. 18095282 Supplier Tocris Bioscience Supplier No. 1375/10

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5-HT2C/2B antagonist/inverse agonist

5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function. Orally active in vivo.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 181629-93-6
Molecular Formula C22H17F4N3O2
Molecular Weight (g/mol) 431.391
InChI Key RRJLJKRFFRZRAF-UHFFFAOYSA-N
Synonym unii-5rdn2e8e97, tocris-1375, chembl14276, n-3-fluoro-5-3-pyrindyl phenyl-2,3-dihydro-5-methoxy-6-trifluoromethyl-1h-indole-1-carboxamide, n-3-fluoro-5-pyridin-3-ylphenyl-5-methoxy-6-trifluoromethyl-2,3-dihydroindole-1-carboxamide, n-3-fluoro-5-3-pyridinyl phenyl-2,3-dihydro-5-methoxy-6-trifluoromethyl-1h-indole-1-carboxamide, lopac-s-2318, d05nwh, gtpl192, n-3-3-pyridinyl-5-fluorophenyl-5-methoxy-6-trifluoromethyl indoline-1-carboxamide
PubChem CID 443390
ChEBI CHEBI:8979
IUPAC Name N-(3-fluoro-5-pyridin-3-ylphenyl)-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide
SMILES COC1=C(C=C2C(=C1)CCN2C(=O)NC3=CC(=CC(=C3)C4=CN=CC=C4)F)C(F)(F)F

Specifications

Quantity 10 mg
Formula Weight 431.39
Percent Purity >99%
Chemical Name or Material SB 228357
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