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SB 203580, Tocris Bioscience™
Selective inhibitor of p38 MAPK
£118.79 - £887.55
Chemical Identifiers
| CAS | 152121-47-6 |
|---|---|
| Molecular Formula | C21H16FN3OS |
| Molecular Weight (g/mol) | 377.437 |
| InChI Key | CDMGBJANTYXAIV-UHFFFAOYSA-N |
| Synonym | 4-4-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-5-yl pyridine, 4-4-fluorophenyl-2-4-methylsulfinyl phenyl-5-4-pyridyl-1h-imidazole, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl-1h-imidazole, chembl10, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl 1h-imidazole, insolution sb 203580, 4-4-4-fluorophenyl-2-4-methylsulfinylphenyl-1h-imidazol-5-yl pyridine, unii-ws78qr6dsv, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl pyridine, pyridine, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl |
| PubChem CID | 176155 |
| IUPAC Name | 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine |
| SMILES | CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
30001347
|
Tocris Bioscience
1202/1 |
1 mg |
£118.79
1mg |
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|
30000722
|
Tocris Bioscience
1202/10 |
10 mg |
£239.73
10mg |
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|
18006042
|
Tocris Bioscience
1202/50 |
50 mg |
£887.55
50mg |
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Description
Selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. Essential component of medium for maintaining stem cells in naive pluripotent state.Water-soluble Salt also available.
Chemical Identifiers
| 152121-47-6 | |
| 377.437 | |
| 4-4-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-5-yl pyridine, 4-4-fluorophenyl-2-4-methylsulfinyl phenyl-5-4-pyridyl-1h-imidazole, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl-1h-imidazole, chembl10, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl 1h-imidazole, insolution sb 203580, 4-4-4-fluorophenyl-2-4-methylsulfinylphenyl-1h-imidazol-5-yl pyridine, unii-ws78qr6dsv, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl pyridine, pyridine, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl | |
| 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine |
| C21H16FN3OS | |
| CDMGBJANTYXAIV-UHFFFAOYSA-N | |
| 176155 | |
| CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F |
Specifications
| 152121-47-6 | |
| 4-4-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-5-yl pyridine, 4-4-fluorophenyl-2-4-methylsulfinyl phenyl-5-4-pyridyl-1h-imidazole, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl-1h-imidazole, chembl10, 4-4-fluorophenyl-2-4-methylsulfinylphenyl-5-4-pyridyl 1h-imidazole, insolution sb 203580, 4-4-4-fluorophenyl-2-4-methylsulfinylphenyl-1h-imidazol-5-yl pyridine, unii-ws78qr6dsv, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl pyridine, pyridine, 4-5-4-fluorophenyl-2-4-methylsulfinyl phenyl-1h-imidazol-4-yl | |
| CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F | |
| 377.437 | |
| 377.44 | |
| SB 203580 |
| C21H16FN3OS | |
| CDMGBJANTYXAIV-UHFFFAOYSA-N | |
| 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine | |
| 176155 | |
| >98% |
Safety and Handling
Recommended Storage : Store at +4°C