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Tocris Bioscience™ SB 202190
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Product Code. 30001220
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Product Code. 30001220 Supplier Tocris Bioscience™ Supplier No. 1264/10

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Description

Potent, selective inhibitor of p38 MAPK

SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Inhibits Yamanaka factor reprogramming of human fibroblasts to iPSCs. SB 202190 improves the self-renewal ability of neuronal stem cells from NPC1-deficient mice.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 152121-30-7
Molecular Formula C20H14FN3O

Specifications

Quantity 10 mg
Formula Weight 331.35
Purity >99%
Molecular Weight (g/mol) 331.35
Chemical Name or Material SB 202190
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