SATB2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA520532

Product Code. 12828712

Description

A suggested positive control is mouse brain tissue lysate. PA5-20532 can be used with blocking peptide PEP-0652.

DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).

Specifications

• Antigen: SATB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SATB2
• Gene Alias: DNA-binding protein SATB2; FLJ21474; FLJ32076; GLSS; KIAA1034; KIAA1034-like DNA binding protein; MGC119474; MGC119477; mKIAA1034; RGD1562369; SATB family member 2; SATB homeobox 2; SATB2; special AT-rich sequence binding protein 2; special AT-rich sequence-binding protein 2; two cut domains-containing homeodomain protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 212712, 23314, 501145
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8VI24, Q9UPW6
• Gene Symbols: SATB2
• Immunogen: A 16 amino acid peptide near the amino terminus of the human SATB2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG