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Invitrogen™ SATB2 Polyclonal Antibody

Product Code. 12828712
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Quantity:
100 μg
Unit Size:
100µg
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12828712 100 μg 100µg
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Product Code. 12828712 Supplier Invitrogen™ Supplier No. PA520532

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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse brain tissue lysate. PA5-20532 can be used with blocking peptide PEP-0652.

DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).
TRUSTED_SUSTAINABILITY

Specifications

Antigen SATB2
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SATB2
Gene Accession No. Q8VI24, Q9UPW6
Gene Alias DNA-binding protein SATB2; FLJ21474; FLJ32076; GLSS; KIAA1034; KIAA1034-like DNA binding protein; MGC119474; MGC119477; mKIAA1034; RGD1562369; SATB family member 2; SATB homeobox 2; SATB2; special AT-rich sequence binding protein 2; special AT-rich sequence-binding protein 2; two cut domains-containing homeodomain protein
Gene Symbols SATB2
Host Species Rabbit
Immunogen A 16 amino acid peptide near the amino terminus of the human SATB2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 212712, 23314, 501145
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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