SASS6 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16810985	Proteintech 21377-1-AP-20UL	20 μL
16800985	Proteintech 21377-1-AP-150UL	150 μL

Description

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Specifications

• Antigen: SASS6
• Applications: Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q6UVJ0
• Gene ID (Entrez): 163786
• Immunogen: SASS6 Fusion Protein Ag15917
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SASS6

• Concentration: 0.42 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: HsSAS 6, SAS 6, SAS6, SASS6
• Gene Symbols: SASS6
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody