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Invitrogen™ SARM Polyclonal Antibody

Product Code. 12838272
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Quantity:
100 μg
Unit Size:
100µg
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12838272 100 μg 100µg
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Product Code. 12838272 Supplier Invitrogen™ Supplier No. PA520059

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Daudi cell lysate. PA5-20059 can be used with blocking peptide PEP-0178.

NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:31439792). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen SARM
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SARM1
Gene Accession No. Q6PDS3, Q6SZW1
Gene Alias A830091I15Rik; C78606; FLJ36296; KIAA0524; MyD885; MyD88-5; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif containing 1; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; tir-1 homolog
Gene Symbols SARM1
Host Species Rabbit
Immunogen A peptide corresponding to amino acids near the C-terminus of human SARM.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23098, 237868
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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