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SAPAP3 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Thermo Scientific PA555312
Additional Details : Weight : 0.02000kg
Description
Immunogen sequence: DSDSGFLAGG RPPGEPGGPF CLEGPDGSYR DLSFKGRSGG SEGRCLACTG MSMSLDGQSV KRSAWHTMMV SQGRDGYPGA GPGKGLLGPE TKAKARTYHY LQVPQ Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
SAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist.Specifications
SAPAP3 | |
Polyclonal | |
Unconjugated | |
DLGAP3 | |
BC058433; DAP3; DAP-3; discs large homolog associated protein 3; discs, large (Drosophila) homolog-associated protein 3; disks large-associated protein 3; DLG associated protein 3; Dlgap3; Prpl8; PSD-95/SAP90-associated protein-3; PSD-95/SAP90-binding protein 3; SAP90/PSD 95 associated protein 3; SAP90/PSD-95-associated protein 3; SAPAP3 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
58512 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
O95886 | |
DLGAP3 | |
Recombinant protein corresponding to Human SAPAP3 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only