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  6. Invitrogen™ SAP102 Recombinant Mouse Monoclonal Antibody (R35001_87C4)

Invitrogen™ SAP102 Recombinant Mouse Monoclonal Antibody (R35001_87C4)

Product Code. 30827828
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30827773 100 μL
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Product Code. 30827828 Supplier Invitrogen™ Supplier No. MA564518
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Estimated Shipment: 20-11-2026
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Description

Mouse Recombinant Monoclonal Antibody

SAP102 Recombinant Monoclonal Antibody for IHC (P)

Synapse-Associated Protein 102 (SAP102) is one of a family of plasma membrane-associated proteins found in synaptic junctions. Like other members of the family, SAP102 has three approximately 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP102 is believed to participate in the clustering of certain proteins, including NMDA receptors, shaker-type potassium channels at the synaptic membrane in CNS neurons. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP102 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP102 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SAP102
Applications Immunohistochemistry (Paraffin)
Classification Recombinant Monoclonal
Clone R35001_87C4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide
Gene DLG3
Gene Accession No. Q92796
Gene Alias discs large homolog 3; discs large MAGUK scaffold protein 3; discs, large homolog 3; discs, large homolog 3 (Drosophila); disks large homolog 3; DLG3; Dlgh3; KIAA1232; mKIAA1232; MRX; MRX90; NEDLG; Neuroendocrine-DLG; PPP1R82; protein phosphatase 1, regulatory subunit 82; PSD-95/SAP90-related protein 1; SAP102; SAP-102; synapse-associated protein 102; XLMR
Gene Symbols DLG3
Host Species Mouse
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1741
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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