Tocris Bioscience™ SAG dihydrochloride

Product Code. 18053842

Brand: Tocris Bioscience™ 6390/10

Description

Dihydrochloride salt of SAG; Smo receptor agonist

SAG dihydrochloride is a water-soluble dihydrochloride salt of SAG (Cat. No. 4366). SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ∼ 3 nM) and induces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons.

Specifications

• Chemical Name or Material: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride
• CAS: 2702366-44-5
• Assay Percent Range: >99%
• Quantity: 10 mg
• Molecular Formula: C₂₈H₂₈ClN₃OS0.2 HCl
• Formula Weight: Observed MW: 562.98
• Purity: 98%