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STEMCELL Technologies SAG

Product Code. 17120222
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Quantity:
1 mg
10 mg
Unit Size:
10mg
1mg
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Product Code. 17120222

Brand: STEMCELL Technologies 73414

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This item is not returnable. View return policy

Description

Hedgehog pathway activator; Activates Smoothened (SMO)

  • SAG (Smoothened Agonist) is a chlorobenzothiophene-containing compound which acts as an activator of the G protein-coupled receptor Smoothened (SMO, EC50 = 3 nM; Chen et al.) SMO is a component of the Hedgehog signaling pathway, which is translocated to the primary cilium after stimulation of the Patched receptor by Hedgehog family ligands, leading to pathway activation
  • SAG activates SMO via direct binding to the heptahelical bundle (Kd= 59 nM), stabilizing a specific conformation of SMO in cilia and leading to increased downstream gene expression (Rohatgi et al.) SAG abrogates cyclopamine inhibition of SMO, indicating that it acts downstream of cyclopamine (Frank-Kamenetsky et al.; Chen et al.; Lewis & Krieg)

Specifications

CAS 912545-86-9
Synonym Smoothened Agonist
Quantity 10 mg
Molecular Formula C28H28ClN3OS
Purity ≥98%
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