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Invitrogen™ SAA4 Polyclonal Antibody
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Product Code. 15508102
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Quantity:
100 μg
Unit Size:
100µg
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15508102 100 μg 100µg
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Product Code. 15508102 Supplier Invitrogen™ Supplier No. PA547606

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Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, approximately 15% cross-reactivity with recombinant human Serum Amyloid A4 is observed and less than 1% cross-reactivity with recombinant mouse Serum Amyloid A1 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Serum Amyloid A4 (SAA4) is a gene that encodes one of the constitutively expressed serum amyloid proteins. Located on chromosome 11, SAA4 is part of the serum amyloid A (SAA) superfamily, which includes other highly homologous genes like SAA1, SAA2, and SAA3. Unlike its counterparts, SAA4 is not an acute-phase reactant but is persistently expressed across different tissues, including plasma, where it associates with high-density lipoprotein (HDL). SAA4 is involved in lipid metabolism and inflammatory responses, albeit not directly induced by inflammatory stimuli like other SAA proteins. It appears as multiple isoforms, some of which may be glycosylated. Recent studies have shown that SAA4 expression encompasses a broad spectrum of physiological conditions and may serve as a marker in diseases involving chronic inflammation and persistent pathological states such as neovascular age-related macular degeneration. The gene's constitutive expression pattern suggests its fundamental role in maintaining homeostasis rather than responding dynamically to acute inflammatory challenges.
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Specifications

Antigen SAA4
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% trehalose and No Preservative
Gene Saa4
Gene Accession No. P31532
Gene Alias amyloid A-5 protein; Constitutively expressed serum amyloid A protein; CSAA; C-SAA; Saa4; Saa-4; Saa5; Saa-5; serum amyloid A 4; serum amyloid A-4 protein; serum amyloid A4, constitutive
Gene Symbols Saa4
Host Species Goat
Immunogen E. coli-derived recombinant mouse Serum Amyloid A4 Asp19-Phe130.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20211
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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