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(S,R,S)-AHPC-Me, MedChemExpress

Product Code. 16421606
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Product Code. 16421606 Supplier Medchem Express Supplier No. HY112078

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Description

MedChemExpress (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

Specifications

Chemical Name or Material (S,R,S)-AHPC-Me
CAS 1948273-02-6
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C23H32N4O3S
Quantity 500 mg
Synonym VHL ligand 2 E3 ligase Ligand 1A
Solubility Information DMSO : 250 mg/mL (562.32 mM; Need ultrasonic)
SMILES N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O
Molecular Weight (g/mol) 444.59
Formula Weight 444.59
Percent Purity 97.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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