(S,R,S)-AHPC hydrochloride, MedChemExpress

Product Code. 16480899

Brand: Medchem Express HY101763A

Description

MedChemExpress (S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

(S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

Specifications

• Chemical Name or Material: (S,R,S)-AHPC hydrochloride
• CAS: 1448189-80-7
• Color: White
• Purity Grade Notes: Research
• Molecular Formula: C₂₂H₃₁ClN₄O₃S
• Quantity: 1 g
• Synonym: VH032-NH2 hydrochlorideVHL ligand 1 hydrochloride
• Solubility Information: DMSO : 250 mg/mL (535.31 mM; Need ultrasonic) ∣H2O : 100 mg/mL (214.12 mM; Need ultrasonic)
• SMILES: O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl
• Molecular Weight (g/mol): 467.02
• Formula Weight: 467.02
• Percent Purity: 95.05%
• Grade: Research
• Physical Form: Powder
• For Use With (Application): Cancer-programmed cell death

Research purposes only