STEMCELL Technologies (S)-MG132

Product Code. 17170192

Brand: STEMCELL Technologies 73262

Description

Ubiquitin-proteasome and NF-κB pathway inhibitor; Inhibits proteasome and stabilizes IκB

• (S)-MG132 is a reversible, cell-permeable inhibitor of proteasome activity (IC₅₀ = 100 nM; Kisselev & Goldberg) and calpain (IC₅₀ = 1.2 μM; Tsubuki et al.) The ubiquitin-proteasome pathway selectively degrades intracellular proteins, thereby clearing damaged or misfolded proteins, and regulating the availability of key proteins involved in the control of inflammatory processes and cell cycle regulation
• (S)-MG132 suppresses NF-κB activation by preventing IκB degradation (IC₅₀ = 3 μM; Arlt et al.), Palombella et al.), Ortiz-Lazareno et al.)
• Blocks apoptosis triggered by DNA damage in HeLa cells (Zhang et al.)
• Inhibits NF-κB activation, sensitizing a variety of carcinoma cell lines to apoptosis (Arlt et al.)
• Cytotoxic effects on a variety of human cancer cell lines (Banerjee & Liefshitz)
• Inhibits growth of mouse melanoma (B16) and human ocular melanoma (IPC227F) cell lines (Vivier et al.)

Specifications

• CAS: 133407-82-6
• Synonym: Z-Leu-Leu-Leu-CHO; Calpain inhibitor IV-2
• Quantity: 1 mg
• Molecular Formula: C₂₆H₄₁N₃O₅
• Purity: ≥98%