Invitrogen™ Ryanodine Receptor Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5109278

Product Code. 17137213

Description

Positive Control: 293T, LOVO, SH-SY-5Y, human fetal skeletal muscle tissue, mouse brain tissue, mouse cerebellum tissue, rat skeletal muscle tissue.

The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the foot region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

Specifications

• Antigen: Ryanodine Receptor
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RYR1
• Gene Alias: 9330127I20Rik; AI528790; ARVC2; ARVD2; Ca2+ release channel; calcium release channel; cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; cardiac muscle-type ryanodine receptor; cardiac ryanodine receptor; cardiac ryanodine receptor 2; cardiac-type ryanodine receptor; CCO; central core disease of muscle; islet-type ryanodine receptor; kidney-type ryanodine receptor; LOW QUALITY PROTEIN: ryanodine receptor 1; MHS; MHS1; PPP1R137; protein phosphatase 1, regulatory subunit 137; ryanodine receptor; ryanodine receptor 1; ryanodine receptor 1 (skeletal); ryanodine receptor 1, skeletal muscle; ryanodine receptor 1-like, skeletal muscle; ryanodine receptor 2; ryanodine receptor 2 (cardiac); ryanodine receptor 2, cardiac; ryanodine receptor type 2; ryanodine receptor type II; RYDR; Ryr; RYR1; RYR-1; Ryr1l; Ryr2; RYR-2; sarcoplasmic reticulum calcium release channel; skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; SKRR; Type 1 ryanodine receptor; type 1-like ryanodine receptor; type 2 ryanodine receptor; unnamed protein product; VTSIP
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6261, 6262
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Form: Liquid

• Applications: Dot Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P21817, Q92736
• Gene Symbols: RYR1, RYR2
• Immunogen: Synthetic peptide within Human RYR2 aa 1,471-1,520.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG