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Ruxolitinib, MedChemExpress

Product Code. 16494027
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Product Code. 16494027

Brand: Medchem Express HY50856

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Description

MedChemExpress Ruxolitinib (INCB18424) is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy.

Ruxolitinib (INCB18424) is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy.

Specifications

Chemical Name or Material Ruxolitinib
Physical Form Powder
CAS 941678-49-5
Color White
Quantity 50 mg
Purity Grade Notes Research
Molecular Formula C17H18N6
For Use With (Application) Cancer-Kinase/protease
Synonym INCB18424
Solubility Information DMSO : ≥ 100 mg/mL (326.40 mM) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES N#CC[C@H](C1CCCC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2
Molecular Weight (g/mol) 306.37
Formula Weight 306.37
Percent Purity 95.37%
Grade Research
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Research purposes only

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