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Invitrogen™ RUSC1 Polyclonal Antibody

Product Code. 12809002
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12809002 100 μg 100µg
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Product Code. 12809002 Supplier Invitrogen™ Supplier No. PA520822

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Description

Rabbit Polyclonal Antibody

A suggested positive control is A-20 cell lysate. PA5-20822 can be used with blocking peptide PEP-0936.

RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with Ikappa-B kinase- (IKK-) -gamma, the regulatory subunit of the IKK complex that is required for NF-kappa-B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappa-B activation pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RUSC1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene RUSC1
Gene Accession No. Q8BG26, Q9BVN2
Gene Alias 2210403N08Rik; AA408288; LOC100360417; Nesca; new molecule containing SH3 at the carboxy-terminus; RP11-21N7.4; RUN and SH3 domain containing 1; RUN and SH3 domain containing 1-like; RUN and SH3 domain-containing protein 1; RUSC1
Gene Symbols RUSC1
Host Species Rabbit
Immunogen A 17 amino acid peptide from near the carboxy terminus of human RUSC1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100360417, 23623, 72296
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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