Invitrogen™ RUNX1T1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA540064

Product Code. 15576751

Description

RUNX1T1 Polyclonal Antibody for ChIP, ChIP-seq, ELISA

RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.

Specifications

• Antigen: RUNX1T1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RUNX1T1
• Gene Alias: acute myelogenous leukemia 1 translocation 1 protein; acute myelogenous leukemia 1 translocation 1, cyclin-D related; AML1-MTG8; AML1T1; Cbfa2t1; CBFA2T1 identified gene homolog; CBFA2T1 isoform r1t1-11a61; CBFA2T1 isoform r1t1-11a62; CBFA2T1 isoform r1t1-11a63; CBFA2T1 isoform r1t1-11a64; CBFA2T1 isoform r1t1-11a65; CBFA2T1 isoform r1t1-7a47; CBFA2T1 isoform r1t1-7a48; CBFA2T1 isoform r1t1-7a49; CBFA2T1 isoform r1t1-7a50; CBFA2T1 isoform r1t1-7a51; CBFA2T1 isoform r1t1-7a52; CBFA2T1 isoform r1t1-7d53; CBFA2T1 isoform r1t1-7d54; CBFA2T1 isoform r1t1-7d55; CBFA2T1 isoform r1t1-7d56; CBFA2T1 isoform r1t1-8a57; CBFA2T1 isoform r1t1-8a58; CBFA2T1 isoform r1t1-8a59; CBFA2T1 isoform r1t1-8a60; Cbfa2t1h; CDR; core-binding factor, runt domain, alpha subunit 2, translocated to, 1; core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related; cyclin D-related; Cyclin-D-related protein; Eight twenty one protein; ETO; LOW QUALITY PROTEIN: protein CBFA2T1; MGC2796; MTG8; MTG8b; myeloid translocation gene on 8q22; protein CBFA2T1; protein CBFA2T1; LOW QUALITY PROTEIN: protein CBFA2T1; protein CBFA2T1-like; Protein ETO; Protein MTG8; runt related transcription factor 1; translocated to, 1 (cyclin D related); runt-related transcription factor 1; translocated to, 1 (cyclin D-related); RUNX1 partner transcriptional co-repressor 1; RUNX1 translocation partner 1; Runx1t1; si:ch211-232j17.1; translocated to, 1; wu:fi14b07; zgc:154044; zinc finger MYND domain-containing protein 2; ZMYND2
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ChIP Assay, ChIP sequencing (ChIP-seq), ELISA
• Concentration: Conc. Not Determined
• Formulation: whole serum with 0.05% sodium azide
• Gene Accession No.: Q06455
• Gene Symbols: RUNX1T1
• Immunogen: Two KLH-conjugated synthetic peptides containing sequences from the N-terminal and the central region of the protein, respectively corresponding to human ETO (runt-related transcription factor 1; translocated to, 1 (cyclin D-related).
• Regulatory Status: RUO
• Gene ID (Entrez): 862
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid