Invitrogen™ RPUSD3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA532069

Product Code. 13476637

Description

Recommended positive controls: mouse brain. Predicted reactivity: Bovine (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

RNA Pseudouridine Synthase D3 (RPUSD3) is a gene that encodes a pseudouridine synthase, an enzyme responsible for catalyzing the isomerization of uridine to pseudouridine in RNA molecules. This post-transcriptional modification is crucial for the stability and function of tRNAs and rRNAs. RPUSD3, along with other pseudouridine synthases such as PUS1, PUSL1, and TRUB2, is predicted to localize to mitochondria, indicating its role in mitochondrial RNA processing and maturation. The pseudouridylation activity provided by RPUSD3 is essential for the proper folding and functionality of mitochondrial RNAs, which are fundamental for the biogenesis of the mitochondrial electron transport chain and ATP synthase. While detailed structural insights into RPUSD3 are not yet fully characterized, its enzymatic function is critical in maintaining cellular energy metabolism and overall mitochondrial health.

Specifications

• Antigen: RPUSD3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RPUSD3
• Gene Alias: AI527266; Mitochondrial mRNA pseudouridine synthase RPUSD3; RGD1307582; RNA pseudouridylate synthase domain containing 3; RNA pseudouridylate synthase domain-containing protein 3; Rpusd3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 101122, 285367
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.65 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q14AI6, Q6P087
• Gene Symbols: RPUSD3
• Immunogen: Recombinant protein encompassing a sequence within the center region of human RPUSD3. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG