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Rottlerin, MedChemExpress

Product Code. 16473626
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25 mg
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Product Code. 16473626 Supplier Medchem Express Supplier No. HY18980

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Description

MedChemExpress Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM.

Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection.

Specifications

Chemical Name or Material Rottlerin
CAS 82-08-6
Color Brown
Purity Grade Notes Research
Molecular Formula C30H28O8
Quantity 25 mg
Synonym Mallotoxin NSC 56346 NSC 94525
Solubility Information DMSO : 12.5 mg/mL (24.20 mM; ultrasonic and warming and heat to 60°C)
SMILES O=C(C1=C2C(C=CC(C)(C)O2)=C(O)C(CC3=C(O)C(C)=C(O)C(C(C)=O)=C3O)=C1O)/C=C/C4=CC=CC=C4
Molecular Weight (g/mol) 516.54
Formula Weight 516.54
Percent Purity 95.0%
Grade Research
Physical Form Powder
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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