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  5. STEMCELL Technologies Rosiglitazone

STEMCELL Technologies Rosiglitazone

Product Code. 17180092
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Product Code. 17180092 Supplier STEMCELL Technologies Supplier No. 72622

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Description

PPARγ activator

  • Rosiglitazone is a potent and selective PPARγ ligand
  • It binds to the PPARγ ligand-binding domain with a Kd of 43 nM (Lehmann et al.) It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC50 values of approximately 30 nM and 100 nM, respectively (Lehmann et al.)
  • Stimulates embryonic mouse neural stem cell proliferation and inhibits neuronal differentiation (Wada et al.)
  • Induces adipocyte differentiation in C3H10T1/2 stem cells (Lehmann et al.)
  • Promotes endothelial differentiation, and inhibits smooth muscle differentiation, in angiogenic progenitor cells (Wang et al.)
  • Stimulates adipocyte differentiation, and decreases osteogenesis, in mouse and human bone marrow-derived mesenchymal stem cells (Ali et al.; Benvenuti et al.; Lecka-Czernik et al.; Sorocéanu et al.)
  • Enhances osteoclast formation in mouse bone marrow cells stimulated with RANKL and M-CSF (Wu et al.)

Specifications

CAS 122320-73-4
Synonym Avandia; BRL 49653
Quantity 10 mg
Molecular Formula C18H19N3O3S
Purity ≥98%
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