Invitrogen™ RORB Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA530152

Product Code. 13404697

Description

Recommended positive controls: HepG2, mouse brain. Predicted reactivity: Mouse (97%), Rat (98%), Zebrafish (86%), Chicken (96%), Sheep (96%), Rhesus Monkey (100%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Retinoid-related orphan receptor beta (ROR beta), a NR1 thyroid hormone receptor, affects the development and functioning of the central nervous system, including sensory input integration and circadian timing. Disruption of ROR beta in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility. ROR beta binds to the monomeric response elements containing the sequence AnnTAGGTCA as a monomer. An alternatively spliced isoform, ROR beta2, has been isolated from rats, and the expression of ROR beta2 is confined to the pineal gland and retina. ROR beta2 shares common DNA- and putative ligand-binding domains with wild-type ROR beta but is characterized by a different amino-terminal domain. ROR beta expression has been documented in various regions of the mouse brain.

Specifications

• Antigen: RORB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RORB
• Gene Alias: bA133M9.1; Nr1f2; Nuclear receptor ROR-beta; nuclear receptor RZR-beta; Nuclear receptor subfamily 1 group F member 2; RAR related orphan receptor B; RAR-related orphan receptor B; RAR-related orphan receptor beta; retinoic acid-binding receptor beta; retinoid-related orphan receptor b; retinoid-related orphan receptor beta; retinoid-related orphan receptor-beta; ror beta; Rorb; Rorbeta; ROR-BETA; rzrb; RZR-beta; sb:eu943; transcription factor; Unknown (protein for IMAGE:7173671)
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 225998, 309288, 6096
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P45446, Q8R1B8, Q92753
• Gene Symbols: RORB
• Immunogen: Recombinant protein encompassing a sequence within the center region of human ROR beta. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG