ROR gamma (t) Rat anti-Mouse, PE, Clone: B2D, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-6981-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15299259

Quantity Price
1 £ 97.22 / 25µg
EU Stock 2
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Description and Specification

Specification

Applications Flow Cytometry (Intracellular Staining)
Quantity 25μg
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Isotype IgG1
Conjugate PE
Concentration 0.2mg/mL
Host Species Rat
Species Reactivity Mouse
Gene Alias Retinoid-Related Orphan Receptor gamma
Format Conjugated
Regulatory Status RUO
Antigen ROR gamma (t)
Clone B2D
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The B2D monoclonal antibody reacts with the mouse ROR gamma (t) protein. ROR gamma is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes ROR alpha and ROR beta. ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes. ROR gamma is expressed in several tissues including liver, lung, muscle, heart and kidney. Furthermore, it was discovered that alternative transcription results in the expression of an isoform, ROR gamma t, which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ “double-positive” thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells of lymphoid organs.

The ROR gamma t isoform differs from ROR gamma by three unique amino acids at the amino terminus. Therefore, the B2D antibody will react with both the ROR gamma and ROR gamma t isoforms.